Bottom side UL Bohemian face a tricky task in their battle against the drop as they take on leaders Lansdowne at Annacotty.
Dolphin are away to second-placed Clontarf and Cork Constitution will be looking to make the most of home advantage count as they welcome Old Belvedere to Temple Hill in a bid to avenge last November's 44-13 defeat by the Dublin side at Anglesea Road.
Shannon are in the Capital as they take on St Mary's College at Templeville Road.
Bruff take on Dungannon in their basement clash in Division 1B at Kilballyowen Park and the South Limerick side will be looking to avenge last November's narrow 12-10 defeat by the Tyrone side at Stevenson Park and pick up valuable points in their bid to avoid the drop to Division 2.
In Division 2A Midleton are away to Bective Rangers and the game will be Jason Holland's last game for the club as he flys back to New Zealand on Monday. Both sides are hovering above the drop zone and Midleton who are hit by injuries must win to have any chance of avoiding relegation.
Cashel take on Galwegians in a mid-table encounter at Crowley Park.
The game of the day in Division 2B sees Thomond and Clonakilty go head to head at Liam Fitzgerald Park with both sides looking to preserve their senior status and avoid a return to Junior ranks.
Sunday's Well are away to third-placed Naas and Nenagh Ormond entertain struggling Ards at the North Tipperary venue.
Richmond get their bid to qualify for the All Ireland League for the second time in their history underway as they take on perennial Connacht champions Monivea at Richmond Park.
The only game in the Munster Junior Cup sees Clanwilliam host near neighbours Clonmel in the last sixteen and the winners will be at home to Munster Junior League champions Richmond in the quarter finals.
Muskerry meet Castleisland at Ellis Park and a win for the Sky Blues will see them regain top spot and be crowned champions of Division Two of the Munster Junior League, but Castleisland can get promoted in a must win game for them.
Mallow currently lead the table but have all their games completed.
Newport will be looking to make the most of home advantage as they take on Ennis in their bid to avoid the drop.
Fellow strugglers and Premier County neighbours Thurles have a tricky task on their hands as they are away to Killarney and Carrick-on-Suir are away to Bandon.
In other ties Kinsale are at home to Dungarvan, who have already been relegated and Youghal welcome Presentation to the East Cork venue.
The Division Three title could be decided at Tanner Park as second-placed Ballincollig take on leaders Killorglin with 'Collig looking to make a quick return to Division 2 and the Kerry side seeking their first promotion.
Fermoy are away to Abbeyfeale and Waterford City are away to Scariff, with Fermoy and City requiring maximum points to keep their promotion aspirations on track.
Douglas take on bottom side Dunmanway-Bantry at the South Cork venue.
FRIDAY 22nd MARCH
Ulster Bank League Division 1A: Garryowen v Young Munster, Dooradoyle, 7.30;
Senior Friendly: U.C.C. v Highfield, Mardyke, 7.30;
Frazer McMullen All Ireland Under 21 Cup Quarter Final: Cork Constitution v Dublin University, Temple Hill, 7.30;
Cleary Cup Final: High School v Abbey CBS / Waterpark, Clonmel, 1.30;
West Under 17 Play Off: Tralee v Abbeyfeale, Tralee, 5.00;
Colleges Womens Division 1 Final: NUIG v U.L., U.L., 4.00;
Colleges Womens Division 2 Final: Waterford IT v Cork IT, U.L. 2.00;
SATURDAY 23rd MARCH
RaboDirect Pro 12: Munster v Connacht, Musgrave Park, 5.45;
Ulster Bank League Division 1A: Clontarf v Dolphin, Castle Avenue, 2.30;
Cork Constitution v Old Belvedere, Temple Hill, 2.30;
St. Mary's College v Shannon, Templeville Road, 2.30;
U.L. Bohemian v Lansdowne, Annacotty, 2.30;
Division 1B: Ballymena v U.C.D., Eaton Park, 2.30;
Bruff v Dungannon, Kilballyowen Park, 2.30;
Buccaneers v Belfast Harlequins, Dubarry Park, 2.30;
Dublin University v Ballynahinch, College Park, 2.30;
Malone v Blackrock College, Gibson Park, 2.30;
Division 2A: Banbridge v Seapoint, Rifle Park, 2.30;
Bective Rangers v Midleton, Donnybrook, 2.30;
Corinthians v Old Wesley, Corinthian Park, 2.30;
D.L.S.P. v Queens University, Kirwan Park, 2.30;
Galwegians v Cashel, Crowley Park, 2.30;
Greystones v City of Derry, Dr. Hickey Park, 2.30;
Terenure College v Old Crescent, Lakelands Park, 2.30;
Division 2B: Boyne v NUIM Barnhall, Drogheda, 2.30;
City of Armagh v Rainey Old Boys, Armagh, 2.30;
Instonians v Suttonians, Shaws Bridge, 2.30;
Naas v Sunday's Well, Fournaughts, 2.30;
Navan v Connemara, Belreask, 2.30;
Nenagh Ormond v Ards, Nenagh, 2.30;
Skerries v Sligo, Hompatrick, 2.30;
Thomond v Clonakilty, Fitzgerald Park, 2.30;
All Ireland Provincial League Championship: Richmond v Monivea, Richmond Park, 2.30;
Portadown v Tullamore, Portadown, 2.30;
Webb Cup: Bruff v Old Crescent, Kilballyowen Park, 12.30;
Newcastle West v Richmond, Newcastle West, 2.30;
Thomond v Young Munster, Fitzgerald Park, 2.30;
Frazer McMullen All Ireland Under 21 Cup Quarter Finals: U.C.D. v U.C.C., Belfield, 2.30;
Lansdowne v Garryowen, Dublin, 2.30;
Young Munster v Old Belvedere, Tom Clifford Park, 2.30;
Schools Junior Cup Final: Castletroy College v Crescent College Comprehensive, Dooradoyle, 3.00;
South Under 19 Cup: Kanturk v Cork Constitution, Kanturk, 11.00;
South Under 19 Development Cup: Dolphin v Clonakilty, Musgrave Park, 12.00;
Mallow v Muskerry-Ballincollig, Mallow, 12.00;
Midleton v Skibbereen, Towns Park, 1.00;
Old Christians v Kinsale, Rathcooney, 12.45;
South Under 17 Cup: Kanturk v Clonakilty, Kanturk, 12.30;
Muskerry v Cobh Pirates, Ballyanly, 12.30;
Skibbereen v Crosshaven, Skibbereen, 12.30;
South Under 17 Development Cup: Ballincollig v Mitchelstown, Tanner Park, 12.00;
Bantry Bay v Bandon, Bandon, 11.30;
Old Christians v Highfield, Rathcooney, 11.30;
South Under 15 Cup: Bantry Bay v Highfield, Mahon, 12.00;
Clonakilty v Skibbereen, The Vale, 11.00;
Midleton v Muskerry, Towns Park, 11.00;
Old Christians v Dolphin, Rathcooney, 11.30;
South Under 15 Development Cup: Kinsale v Cobh Pirates, Kinsale, 11.30;
Sunday's Well v Mitchelstown, Mahon, 10.30;
West Under 15 Cup Quarter Finals: Castleisland v Killorglin, Castleisland, 11.00;
Iveragh v Corca Dhuibhne, Cahirciveen, 11.00;
Killarney v Tralee, Killarney, 11.00;
Listowel v Tralee Barbarians, Listowel, 11.00;
West Under 13 League Playoff: Killorglin v Tralee, Killorglin, 11.00;
Girls Under 18: South Cork v Carrick-on-Suir, Moneygourney, 12.30;
Thurles v Mallow, Moneygourney, 12.30;
SUNDAY 24th MARCH
Munster Junior Cup: Clanwilliam v Clonmel, Clanwilliam Park, 2.30;
Munster Junior League Division 2: Bandon v Carrick-on-Suir, Bandon, 2.30;
Killarney v Thurles, Killarney, 2.30;
Kinsale v Dungarvan, Kinsale, 2.30;
Muskerry v Castleisland, Ballyanly, 2.30;
Newport v Ennis, Newport, 2.30;
Youghal v Presentation, Youghal, 2.30;
Division 3: Abbeyfeale v Fermoy, Abbeyfeale, 2.30;
Ballincollig v Killorglin, Tanner Park, 2.30;
Douglas v Dunmanway-Bantry Bay, Moneygourney, 2.30;
Scariff v Waterford City, Scariff, 2.30;
Munster Seconds League Quarter Finals: Cork Constitution v Bruff, Temple Hill, 2.30;
U.L. Bohemian v Cashel, Annacotty, 2.30;
Highfield v Garryowen, Woodleigh Park, 2.30;
Young Munster v U.C.C., Clifford Park, 2.30;
County Cup: Kanturk v Old Christians, Kanturk, 2.30;
Midleton v Skibbereen, Towns Park, 2.30;
Garryowen Cup Final: Kilfeacle v Nenagh Ormond, Cashel, tbc;
South Junior 2 Cup: Cashel v Kanturk, Cashel, 2.30;
Castleisland v Cobh Pirates, Castleisland, 2.30;
Clonakilty v Iveragh, The Vale, 2.30;
Cork Constitution v Waterford City, Temple Hill, 2.30;
Shandon v Carrigaline, Whitechurch, 2.30;
Webb Cup: Fethard v Kilrush, Fethard, 2.30;
Kelly Cup: Bandon v Skibbereen, Bandon, 12.00;
Casey Cup: Waterpark v Dungarvan, Ballinakill, 2.30;
South Junior 3 Cup: Midleton v Dolphin, Towns Park, 12.00;
East Under 19 Cup Semi Final: Waterpark v Clonmel, Ballinakill, 2.00;
East Under 17 Cup: Cashel v Clonmel, Cashel, 11.00;
Kilfeacle v Galbally, Kilfeacle, tbc;
Nenagh Ormond v Carrick-on-Suir, Nenagh, 12.00;
East Under 15 Cup: Nenagh Ormond v Fethard, Nenagh, 11.00
Waterpark Dev v Dungarvan, Ballinakill, 11.00;
East Under 15 Plate: Carrick-on-Suir v Kilfeacle, Carrick-on-Suir, 11.00;
Clanwilliam v Clonmel, Clanwilliam Park, 11.00;
East Under 13 Cup Semi Finals: Kilfeacle v Fethard, Kilfeacle, 11.00;
Nenagh Ormond v Waterpark, Nenagh, 11.00
East Under 13 Plate: Galbally v Waterpark, Galbally, tbc;
Waterford City v Clonmel, Waterford, tbc;
North Under 19 Cup: Bruff v Garryowen, Kilballyowen Park, 12.30;
Thomond v Shannon, Liam Fitzgerald Park, 12.30;
North Under 17 Cup: Kilrush v Bruff, Kilrush, 12.00;
Old Crescent v U.L. Bohemian, Rosbrien, 11.30;
North Under 15 Cup: Bruff v Richmond, Kilballyowen Park, 11.00;
Presentation-Newport v St. Senan's, Rathuard, 11.30;
Thomond v Shannon, Liam Fitzgerald Park, 11.00;
North Under 14 Cup: Ennis v Young Munster, Ennis, 11.30;
Garryowen White v Ballina-Killaloe, Dooradoyle, 11.30;
Shannon v U.L. Bohemian, Coonagh, 11.30;
St. Senan's v Bruff, Jim Slattery Park, 11.30;
North Under 14 Conference Final: Kilrush v Newcastle West, Coonagh, 12.00;
North Under 13 Cup: Bruff v Kilrush, Kilballyowen Park, 12.00;
South Under 19 League Semi Final: Sunday's Well v Highfield, Musgrave Park, 2.30;
Womens All Ireland Cup Semi Finals: Blackrock College v U.L. Bohemian, Stradbrook, 1.00;
Highfield v Old Belvedere, Woodleigh Park, 1.00;
Womens All Ireland Plate Semi Final: St. Mary's College v Ballincollig, Templeville Road, 1.00;
WEDNESDAY 27th MARCH
East Under 17 Plate: Waterford City v Fethard, Waterford, 7.30;
South Under 17 Cup: Highfield v Midleton, Woodleigh Park, 5.00;