Ireland's all time record 24 times try scorer will lead out an unchanged team from that which defeated Scotland to win the Triple Crown in March.
A 65th cap for second row Malcolm O'Kelly brings him to within four of the Irish all time capped record haul of 69, established by Mike Gibson between 1964 and '79.
Other cap milestones in Bloemfontein will see prop John Hayes reach the 45 mark; blind side flanker Simon Easterby win his 33rd cap; hooker Shane Byrne and winger Shane Horgan win their 30th caps and second row Paul O'Connell and open side flanker David Wallace make their 20th appearances.
Alan Quinlan's selection in the replacements represents his first time in the Match 22 since he injured a shoulder while scoring a try against Argentina in the World Cup in Australia in October 2003.
The Ireland team to play South Africa at Bloemfontein on Saturday next, June 12th as follows:
15 - Girvan Dempsey (Leinster - Terenure College) 14 - Shane Horgan (Leinster - Lansdowne) 13 - Gordon Darcy (Leinster - Lansdowne) 12 - Brian O'Driscoll (Leinster - Blackrock College) Captain 11 - Geordan Murphy (Leicester) 10 - Ronan O'Gara (Munster - Cork Constitution) 9 - Peter Stringer (Munster - Shannon) 1 - Reggie Corrigan (Leinster - Greystones) 2 - Shane Byrne (Leinster - Blackrock College) 3 - John Hayes (Munster - Shannon) 4 - Malcolm O'Kelly (Leinster - St. Mary's College) 5 - Paul O'Connell (Munster - Young Munster) 6 - Simon Easterby (Llanelli) 7 - David Wallace (Munster - Garryowen) 8 - Anthony Foley (Munster - Shannon)
Replacements: 16 - Frankie Sheahan (Munster - Cork Constitution), 17 - Marcus Horan (Munster - Shannon), 18 - Donncha O'Callaghan (Munster - Cork Constitution), 19 - Alan Quinlan (Munster - Shannon), 20 - Guy Easterby (Rotherham), 21 - David Humphreys (Ulster - Dungannon), 22 - Kevin Maggs (Bath).