In the back division, Ugo Monye has recovered from a hand injury and starts on the left wing. Monye returns to the starting XV for the first time since the Zurich Premiership fixture against Gloucester on 9th October, with his last appearance for Quins being as a replacement against Leeds Tykes on 28th November.
Simon Keogh moves over to the right wing and replaces George Harder, who dislocated a finger in training yesterday.
In the pack, there are two changes in the back row. Nick Easter and Tony Diprose take over from Maama Molitika and Kai Horstmann on the blindside flank and at number eight respectively. Andre Vos misses out due to an ankle injury, so Luke Sherriff continues on the openside flank and Diprose captains the side.
On the bench, James Hayter returns from a groin injury and replaces Cameron Dott and there is also a place for Roy Winters, having missed the game against Castres last weekend.
NEC Harlequins 15. Gavin Duffy 14. Simon Keogh 13. Dafydd James 12. Mel Deane 11. Ugo Monye 10. Andy Dunne 9. Steve So oialo 1. Ceri Jones 2. Ace Tiatia 3. Jon Dawson 4. Karl Rudzki 5. Simon Miall 6. Nick Easter 7. Luke Sherriff 8. Tony Diprose (Capt.) Replacements: 16. James Hayter, 17. Tom Muggridge, 18. Roy Winters 19. Maama Molitika, 20. Andy Reay, 21. Jeremy Staunton 22. Tom Williams