Mullins comes staright into the backline to replace Gavin Duffy while Holland is drafted onto the bench in place of Mark McHugh who takes over in the starting line-up from Gordon D'Arcy who has also been forced to withdraw.
15 Mark McHugh (Leinster/St Mary's College 14 James Topping (Ulster/Ballymena) 13 Mike Mullins (Munster/Old Crescent) 12 David Quinlan (Leinster/Blackrock College) 11 Tyrone Howe (Ulster/Dungannon) 10 Barry Everitt (London Irish) 9 Brian O Meara (Leinster/ Cork Constitution) 1 Emmett Byrne (Leinster/St.Mary s College) 2 Paul Shields (Ulster/Ballymena) 3 Simon Best (Ulster/Belfast Harlequins) 4 Donnacha O Callaghan (Munster/Cork Constitution) 5 -Jeremy Davidson captain (Ulster/Dungannon) 6 Simon Easterby (Llanelli) 7 Kieron Dawson (London Irish) 8 Des Dillon (Leinster/UCD).
Replacements: 16 James Blaney (Munster/Shannon), 17 Peter Bracken (Connacht/Galwegians), 18 Mick O Driscoll (Munster/ Cork Constitution), 19 Aidan McCullen (Leinster/Lansdowne) 20 Michael Prendergast (Munster/Young Munster) 21 Jason Holland (Munster/Midleton) 22 Anthony Horgan (Munster/Cork Constitution)
England: D Scarbrough; P Christophers, F Waters, B Johnston, M Cueto; A King, A Gomarsall; J Forrester, A Vander, M Corry (capt.), C Jones, S Shaw, R Morris, M Regan, M Worsley.
Replacements: A Titterrell, M Fitzgerald, T Palmer, H Vyvyan, N Walshe, O Barkley, M Stephenson.
Referee: G Davis (Scotland).