It's also a first Heineken Cup start for Felix Jones whose European competition experience has been confined to Munster's Amlin Challenge Cup games last season
In the backs, there are two changes where a return from injury by Denis Hurley and Conor Murray sees Johne Murphy and Tomas O'Leary slip to the bench.
Up front Wian du Preez starts his seventh consecutive Heineken Cup game and Donnacha Ryan and Paul O'Connell return from injury.
In the back row, Peter O'Mahony switches from seven to six and O'Donnell is preferred to David Wallace who is named on the bench.
Munster: F Jones; D Hurley, K Earls, L Mafi, S Zebo; R O'Gara, C Murray; W du Preez, M Sherry, BJ Botha; D Ryan, P O'Connell; P O'Mahony, T O'Donnell, J Coughlan. Replacements: D Varley, M Horan, S Archer, D O'Callaghan, D Wallace, T O'Leary, I Keatley, J Murphy.