Jerry Flannery who was named in the extended squad misses out because of what management describe as 'a slight Achilles problem'.
In the backline, coach Tony McGahan has opted for a Mafi/Earls midfield combination while Denis Hurley after a short but impressive role as a replacement against Ospreys last week edges out Ian Dowling.
Munster: P Warwick; D Howlett, K Earls, L Mafi, D Hurley; R O'Gara, T O'Leary; W du Preez, D Fogarty, J Hayes; D O'Callaghan, P O'Connell capt; A Quinlan, D Wallace, D Leamy. Replacements: D Varley, D Hurley, T Buckley, M O'Driscoll, D Ryan, N Ronan, P Stringer, J de Villiers.
Perpignan: J Porical, F Sid, D Marty, M Mermoz, C Manas, G Hume, N Durand, P Freshwater, G Guirado, N Mas [capt], O Olibeau, R Tchale Watchou, Y Vivalda, B Guiry, Y Parent Replacements: M Tincu, J Schuster, K Pulu, C Geli, D Mele, J Grandclaude, P Burger, R Alvarez Kairelis
Referee: Wayne Barnes (England)