Murphy, who scored the final try of the night in Belfast and was one who impressed, takes over from Luke O'Dea who scored Munster's opening try that night but sustained an ankle injury that ruled him out of consideration for this one.
Otherwise, just five players, Denis Hurley, Lifeimi Mafi, Wian du Preez, Damien Varley and James Coughlan retain their places from that night in Ulster.
Niall Ronan returns to the openside where Tommy O'Donnell started last day but ended with a knee injury and Peter O'Mahony, out with a jaw injury also resumes at the expense of Dave O'Callaghan who gave another good account of himself in Ravenhill last weekend and looks to have been a very shrewd inclusion by McGahan in Munster's Heineken Cup squad.
Munster: D Hurley; J Murphy, K Earls, L Mafi, S Zebo; R O'Gara, C Murray; W du Preez, D Varley, BJ Botha; D Ryan, P O'Connell capt; P O'Mahony, N Ronan, J Coughlan. Replacements: D Fogarty, M Horan, S Archer, Donncha O'Callaghan, B Holland, T O'Leary, I Keatley, D Barnes.