There's a first start for academy player Luke O'Dea, a first start of the season for Tomas O'Leary, a first start of the season at full back for Denis Hurley and O'Driscoll and Donncha O'Callaghan paired in the second row for the first time since the Harlequins game last season.
The almost wholesale change in personnel provides opportunities according to Assistant Coach Anthony Foley, " Look, whatever side is selected, the players all train together, all sit down and review and preview the opposition. They work together in training. So everyone understands what's required."
"They've (Edinburgh) come off the back of two great weekends in Europe but so have we and with the game in Thomond Park with hopefully a massive support, the opportunity is there for fellas to make a case for themselves because there are places up for grabs in the team."
Munster: Denis Hurley; Luke O'Dea, Will Chambers, Danny Barnes, Simon Zebo; Ian Keatley, Tomas O'Leary; Marcus Horan, Denis Fogarty, Stephen Archer; Donncha O'Callaghan, Mick O'Driscoll capt; Billy Holland, Tommy O'Donnell, Paddy Butler. Replacements: Sean Henry, John Ryan, John Hayes, Ian Nagle, James Coughlan, Duncan Williams, Tom Gleeson, Scott Deasy.
Not considered because of injury: D Wallace, J Flannery, Donnacha Ryan, Denis Leamy, M Sherry, P Borlase, Darragh Hurley, Dave O'Callaghan, K Earls, F Jones, I Dineen, S Scanlon, T Smith.