Ian Keatley and Johne Murphy form an exciting new centre partnership with Gerhard van den Heever and Simon Zebo keeping their places in the side after both touched down last weekend. Zebo moves to the left wing with Jones coming in at full-back.
Cathal Sheridan makes his first start since injuring his knee against Ulster in January and partners JJ Hanrahan in the half-backs.
Hooker Duncan Casey is the only player that keeps his place in the front row with James Cronin, who is set to earn his 20th cap, and South African BJ Botha coming into the side.
Captain Billy Holland, who recently signed a two-year contract extension, joins Ryan in the second row.
Dave O'Callaghan comes into the back row for his first start since December with O'Donnell returning from international duty and CJ Stander moving to no. 8 as he maintains his place in the side.
Young Munster hooker Ger Slattery provides the front-row cover alongside Irish international Dave Kilcoyne and John Ryan.
Donncha O'Callaghan is poised to make a record-breaking appearance off the bench as he looks to make his 241st appearance and become the most-capped Munster player of all time.
Sean Dougall made his comeback from injury against Cardiff Blues and he is also named on a replacements bench that includes Duncan Williams, Denis Hurley and Andrew Conway.
Tickets are available from the Ticket Offices in Musgrave Park and Thomond Park today until 5pm and from the Ticketmaster van outside the Dolphin Gate tomorrow from 9am.
Munster: Felix Jones; Gerhard van den Heever, Johne Murphy, Ian Keatley, Simon Zebo; JJ Hanrahan, Cathal Sheridan; James Cronin, Duncan Casey, BJ Botha; Donnacha Ryan, Billy Holland (Capt); Dave O'Callaghan, Tommy O'Donnell, CJ Stander. Replacements: Ger Slattery, Dave Kilcoyne, John Ryan, Donncha O'Callaghan, Sean Dougall, Duncan Williams, Denis Hurley, Andrew Conway.