Munster's Tadhg Beirne, Keith Earls, Conor Murray, Peter O'Mahony and CJ Stander will start for Ireland with Dave Kilcoyne among the replacements for Sunday's Guinness Six Nations opener against Wales in Cardiff.
Johnny Sexton will captain the side as he competes in his twelfth Six Nations Championship and his second as Ireland captain. He is joined in the half-backs by Murray who is one of five players from the match day squad who played in Ireland’s last Six Nations victory in Cardiff in 2013 (Murray, Sexton, Healy, O’Mahony, Earls).
Robbie Henshaw and Garry Ringrose are partnered in midfield having last started a Test match together in the quarter-final of the 2019 Rugby World Cup. Hugo Keenan is selected at fullback with support on the wings from Earls and James Lowe, who makes his Six Nations debut.
Cian Healy, who makes his 50th Six Nations appearance, is joined in the front row by Rob Herring and Andrew Porter. Beirne and James Ryan form the lock partnership with O’Mahony, Josh van der Flier and Stander named in the backrow.
The replacements are Ronan Kelleher, Kilcoyne, Tadgh Furlong, Iain Henderson, Will Connors, Jamison Gibson Park, Billy Burns and Jordan Larmour.
The game kicks off at 3pm on Sunday and will be televised on Virgin in the Republic of Ireland and on BBC in Northern Ireland.