James Downey comes into the side to make his 40th Munster appearance with Casey Laulala drafted into the starting XV to form a solid centre pairing.
Andrew Conway starts on the right wing in place of Gerhard van den Heever and Ian Keatley shifts from centre to out-half with Cathal Sheridan maintaining his place at scrum-half.
Jones starts at full-back with Simon Zebo, who has four tries in his last three appearances, on the left wing.
There's an unchanged front-row as James Cronin, Duncan Casey and BJ Botha keep their places.
Dave Foley comes into the team to partner Ryan in the second-row with James Coughlan captaining the side from no.8. Tommy O'Donnell and Sean Dougall, making his first start since injuring his ankle against Connacht in December, complete a dynamic back-row.
In the replacements, Young Munster's Ger Slattery will be hoping for a repeat of last week's two-try performance off the bench with Irish internationals Kilcoyne and Stephen Archer completing the front-row cover.
Record appearance holder Donncha O'Callaghan and last week's man-of-the-match CJ Stander are also named on the bench with Duncan Williams, JJ Hanrahan and Denis Hurley providing the cover for the backs.
Munster face Ospreys at the Liberty Stadium on Sunday afternoon at 4pm. The game will be televised live on S4C with updates here.
Munster: Felix Jones; Andrew Conway, Casey Laulala, James Downey, Simon Zebo; Ian Keatley, Cathal Sheridan; James Cronin, Duncan Casey, BJ Botha; Donnacha Ryan, Dave Foley; Tommy O'Donnell, Sean Dougall, James Coughlan(Capt). Replacements: Ger Slattery, Dave Kilcoyne, Stephen Archer, Donncha O'Callaghan, CJ Stander, Duncan Williams, JJ Hanrahan, Denis Hurley.