Penney has made six changes to the side that extended Munster's winning run to five games last weekend against Newport Gwent Dragons at Rodney Parade.
There are three changes in the backs with Murray coming in to partner last week's man of the match Ian Keatley in the half-backs.
Casey Laulala returns to the side and lines up alongside James Downey in the centre positions.
Laulala's inclusion means that Keith Earls moves out to the right wing with Johne Murphy coming into the side on the left wing and Felix Jones keeping his place at full-back.
Damien Varley is the only change in the front row as the hooker replaces the injured Mike Sherry with Irish internationals Dave Kilcoyne and Stephen Archer keeping their places in the side.
The second row of Donncha O'Callaghan and Paul O'Connell remains the same but there are two changes in the back row with Peter O'Mahony and Sean Dougall coming into the team.
James Coughlan starts at no.8 after recovering from an eye injury sustained against Newport Gwent Dragons last weekend.
Billy Holland is named on the bench for the first time in this season's Heineken Cup alongside Shannon hooker Duncan Casey who could make his competitive debut for the province.
Munster currently lie second in Pool 6 of the Heineken Cup, a point behind Perpignan.
Category A and B tickets are now sold-out for the game with only terrace tickets remaining.
There are still North Terrace Family Packs available for just €40 for one adult and one junior (under 16).
Terrace Tickets can be purchased here and on match day.
Munster: Felix Jones; Keith Earls, Casey Laulala, James Downey, Johne Murphy; Ian Keatley, Conor Murray; Dave Kilcoyne, Damien Varley, Stephen Archer; Donncha O'Callaghan, Paul O'Connell; Peter O'Mahony (Capt.), Sean Dougall, James Coughlan
Replacements: Duncan Casey, James Cronin, BJ Botha, Billy Holland, CJ Stander, Cathal Sheridan, JJ Hanrahan, Denis Hurley