Botha suffered a calf strain in training in the run up to the Cardiff game while Horan succumbed to a bout of illness. Nagle has been out of action after sustaining a shoulder injury in the pre-season game against London Irish in Thomond Park Stadium in late August.

Munster Squad (29) v Edinburgh: J Murphy, S Deasy, S Zebo, T Gleeson, D Barnes, L Mafi, D Hurley, D Howlett, P Stringer, D Williams, I Keatley, M Horan, J Hayes, W du Preez, J Ryan, S Archer, BJ Botha, D Fogarty, M Sherry, B Holland, M O'Driscoll, I Nagle, D Foley, D O'Callaghan, P O'Mahony, N Ronan, T O'Donnell, P Butler, J Coughlan