Donnacha Ryan will take O'Connell's place alongside Donncha O'Callaghan with O'Driscoll on the bench and the side will now be led by Ronan O'Gara.

O'Connell is expected to be fully recovered in time for the game next week against Perpignan.

Munster: P Warwick; D Howlett, J de Villiers, L Mafi, K Earls; R O'Gara, T O'Leary; W du Preez, D Fogarty, J Hayes; D O'Callaghan,  D Ryan; A Quinlan, N Ronan, J Coughlan. Replacements: D Varley, T Buckley, M O'Driscoll, N Williams, P Stringer, I Dowling, D Hurley.
Ospreys: G Owen; T Bowe, S Parker, A Bishop, N Walker; D Biggar, L Davies; D Jones, R Hibbard, C Mitchell; A-Wyn Jones, J Thomas; J Collins, M Holah, F Tiatia. Replacements: H Bennett, P James, C Griffiths, A Lloyd, B Lewis, R Webb, J Hook.