Danny Barnes will partner Johne Murphy in the centre while Simon Zebo takes over from Keith Earls on the wing.
O'Gara, who will win his 206th Munster cap tomorrow was honoured at a Civic Reception in Cork City Hall last night to mark his contribution to a sport he was illuminated since first making his Munster senior debut back in August 1997.
Togging out with him on Friday will be his colleague through all those years, Alan Quinlan who wins his 211th Munster cap.
Munster: F Jones; D Howlett, J Murphy, D Barnes, S Zebo; R O'Gara, T O'Leary; M Horan, M Sherry, J Hayes; D Ryan, P O'Connell capt; A Quinlan, N Ronan, D Leamy. Replacements: D Varley, W du Preez, S Archer, I Nagle, T O'Donnell, P Stringer, P Warwick, D Hurley.