Up front, Wian du Preez steps in for Marcus Horan and at tight head Stephen Archer comes in for John Hayes while Mick O'Driscoll will be partnered by Billy Holland in the second row and Tommy O'Donnell breaks into the back row in place of Niall Ronan.
Interesting newcomer to the match day squad is 23 year old prop John Ryan. The former Ireland Schools, U19/20 international was drafted into the squad in place of Horan who is suffering from illness.
The Blues won their opening two games but went down 20-3 last weekend in Ravenhill. Their record against Munster in Cardiff is good however. Although McGahan's side side won there last season you have to go back to November 2005 for the last time that Munster won in the Welsh capital.
Munster: J Murphy; D Howlett, D Barnes, L Mafi, D Hurley; I Keatley, D Williams; W du Preez, M Sherry, S Archer; B Holland, M O'Driscoll; P O'Mahony capt, T O'Donnell, J Coughlan. Replacements: D Fogarty, J Ryan, J Hayes, D Foley, N Ronan, P Stringer, S Deasy, T Gleeson.