Coaches Eric Elwood and Anthony Foley included Nagle in the squad after fellow Munster man Donnacha Ryan and Ulster's Dan Tuohy, both named in the original squad, were ruled out due to injury.
Damien Varley and Tony Buckley start in the frontrow with Tomas O'Leary, Denis Hurley and Johne Murphy named in the backline.
The O2 Ireland Wolfhounds play Scotland 'A' in Netherdale this Friday, January 28th, ko 7.30pm.
In their final outing the Ireland Wolfhounds will take on the England Saxons the following Friday, Feb. 4th, in Ravenhill, ko 7.30pm.
O2 Ireland Wolfhounds Team and Replacements:
15. Gavin Duffy (Galwegians - Connacht)
14. Johne Murphy (Young Munster - Munster)
13. Eoin O'Malley (Old Belvedere - Leinster)
12. Nevin Spence (Ballynahinch - Ulster)
11. Denis Hurley (Cork Constitution - Munster)
10. Ian Humphreys (Ballymena - Ulster)
9. Tomás O'Leary (Dolphin - Munster)
1. Brett Wilkinson (Galwegians - Connacht)
2. Damien Varley (Garryowen - Munster)
3. Tony Buckley (Shannon - Munster)
4. Ian Nagle (Cork Constitution - Munster)
5. Devin Toner (Lansdowne - Leinster)
6. Kevin McLaughlin (St. Mary's College - Leinster)
7. Willie Faloon (Ballynahinch - Ulster)
8. Chris Henry (Ballymena - Ulster) Captain
16. Nigel Brady (Dungannon - Ulster)
17. Jamie Hagan (Corinthians - Connacht)
18. Andrew Browne (Galwegians - Connacht)
19. Dominic Ryan (Lansdowne - Leinster)
20. Isaac Boss (Terenure College - Leinster)
21. Niall O'Connor (Belfast Harlequins - Ulster)
22. Ian Whitten (Ballynahinch - Ulster)