Joining O'Donoghue in the starting XV is fellow Irish U20s player Dan Goggin (Young Munster) who starts at outside centre with academy players Alex Wootton, Niall Kenneally, Darren Moroney and last year's Munster U19s captain Steve McMahon (Garryowen) all named in the backline.
The half-back pairing sees UCD's Jamie Glynn and Lansdowne's Tom Kiersey both start. Glynn made his Munster A debut in February when coming on as a replacement against Connacht Eagles.
The front row have all played at Munster A level this season and includes academy prop Niall Horan, UL Bohemians hooker Kevin O'Byrne and dual status player Mike Lynch of St.Senans/UL Bohs.
Academy lock Sean McCarthy, who made his B&I Cup debut last Friday against Leinster, joins Cork Con's Joe McSweeney in the second row while sub-academy player Diarmuid Dee (Young Munster) starts at blindside with academy players Ryan Murphy and Captain O'Donoghue completing the back-row.
The extended bench includes academy players John Madigan, Shane Buckley, Brian Haugh, Harry McNulty and Greg O'Shea.
Harry McNulty's brother Sean (UCD) is named as replacement hooker while Aidan Butler, brother of Paddy, is named as back-row cover.
Munster Development XV: Steve McMahon, Darren Moroney, Dan Goggin, Niall Kenneally, Alex Wootton; Tom Kiersey, Jamie Glynn; Niall Horan, Kevin O'Byrne, Mike Lynch; Sean McCarthy, Joe McSweeny; Diarmuid Dee, Ryan Murphy, Jack O'Donoghue Capt.
Replacements from: Sean McNulty, Conor Glynn, Ger Sweeney, Lee Nicholas, John Madigan, Shane Buckley, Aidan Butler, Luke Cahill, Brian Haugh, Sam Sterling, Harry McNulty, Greg O'Shea.
Free admission with entry via the Dolphin and Sunday's Well gates.