Sean Dougall, Dave Kilcoyne and man of the match Keith Earls all touched down in the opening 40 to give Munster a commanding 22-0 half-time lead.
A penalty try secured the bonus point with 15 minutes remaining and James Coughlan scored a fifth try late on.
Conor Murray was forced off in the opening quarter with a knee injury and is expected to miss next Saturday's return clash against Perpignan.
Ian Keatley(dead leg) and Felix Jones (cramp) also hobbled off but are expected to be available for selection next weekend.
Munster face Perpignan in the return fixture at Stade Aime Giral next Saturday (ko 4:40pm French time).
Munster A face Plymouth Albion in the British and Irish Cup this Friday at Waterford's Regional Sports Centre (ko 7:30pm).
Tickets for that game can be purchased online here.