Murphy who travelled as a backs reserve last weekend comes straight in to the starting team as does Peter O'Mahony who was ruled out of the Edinburgh clash. James Coughlan makes way for Peter this Saturday and Donnacha Ryan shifts to blind-side replacing the injured Paddy Butler.
Donncha O'Callaghan resumes his second row partnership with Paul O'Connell as Varley and Botha join Kilcoyne in the front row. Cathal Sheridan takes the place of Duncan Williams in the replacements.
Munster: Felix Jones; Keith Earls, Casey Laulala, James Downey, Johne Murphy; Ian Keatley, Conor Murray; Dave Kilcoyne, Damien Varley, BJ Botha; Donncha O'Callaghan, Paul O'Connel; Donnacha Ryan, Niall Ronan, Peter O'Mahony Capt. Replacements: Mike Sherry, James Cronin, Stephen Archer, James Coughlan, CJ Stander, Cathal Sheridan, JJ Hanrahan, Denis Hurley.
Category B Stand and North/South Terrace tickets are on sale for this weekend's game with Cat A tickets and East/West Terrace tickets sold out at this stage.
Tickets are on sale online here, from the Munster Rugby ticket offices in Thomond Park and Musgrave Park, Ticketmaster outlets nationwide, or by calling 0818 719300. Tickets will be available to purchase on match-day.
Ticket Prices: €30 Terrace, €40 Cat B.