Keith Earls shifts in from the wing to start in the number 13 jersey in a new centre partnership with Ivan Dineen.
Felix Jones is also in line to make his first appearance of the season after recovering from shoulder surgery as he is named amongst the substitutes.
Munster: Johne Murphy; Andrew Conway, Keith Earls, Ivan Dineen, Simon Zebo; JJ Hanrahan, Cathal Sheridan; James Cronin, Damien Varley, John Ryan; Donncha O'Callaghan, Dave Foley; Peter O'Mahony (Capt.), Sean Dougall, Paddy Butler. Replacements: Mike Sherry, David Kilcoyne, Stephen Archer, Paul O'Connell, CJ Stander, Duncan Williams, Ian Keatley, Felix Jones.