Johne Murphy and Keith Earls who were on the wings for last weekend's Heineken Cup round, make positional switches to fullback and outside centre respectively.
Penney starts with a new front row for Friday's encounter with James Cronin making his third league start as he lines up next to Mike Sherry and Stephen Archer, and CJ Stander joins Sean Dougall and Peter O'Mahony in the back-row.
Head Coach Rob Penney talking about the changes to this week's side commented "Due to the short turn-around and the travel and intensity of the last three weeks, and the importance of the next two weeks, there is a bit of freshening up in the group and this is why we've made a few changes.
Glasgow are top of the table, semi-finalists who probably should have been in the final last year and they are the form team in the Rabo in at least the last nine months. It doesn't get more difficult than playing them at their home ground and it's as big as it gets in the Rabo at this time of the year."
Munster: Johne Murphy; Andrew Conway, Keith Earls, Ivan Dineen, Ronan O'Mahony; JJ Hanrahan, Conor Murray; James Cronin, Mike Sherry, Stephen Archer; Donncha O'Callaghan, Paul O'Connell; Peter O'Mahony Capt., Sean Dougall, CJ Stander. Replacements: Damien Varley, Dave Kilcoyne, BJ Botha, Billy Holland, James Coughlan, Cathal Sheridan, James Downey, Casey Laulala.
Referee: Ian Davies
Broadcasters: TG4 and BBC Alba