Munster touched down six tries on their way to their biggest win of the season as they finished the pool stages in style.
Man-of-the-match James Coughlan scored the first try with Johne Murphy adding the second midway through the first half. Conor Murray crossed for the third early in the second half before captain Peter O'Mahony secured the bonus-point just short of the hour. Substitute Simon Zebo and Felix Jones scored late on to seal a memorable win.
Munster now advance to a mouth-watering home quarter-final against Toulouse at Thomond Park in the first week of April.